Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL), also known as B-cell chronic lymphocytic leukemia (B-CLL), is a disorder associated with morphologically mature but immunologically less mature lymphocytes, which accumulate in the bone marrow, lymphatic tissue and blood. CLL is often characterized by the expression of B-cell antigens CD19, CD20, CD23 and CD5, as well as relatively low surface membrane immunoglobulin. This immunophenotype as well as an absolute increase in bone marrow infiltration and/or lymphocytosis can be used to diagnose CLL.

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